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doi: 10.1038/s41568-024-00681-y 44 Nouri-ShiraziMBanchereauJBellDBurkeholderSKrausETDavoustJet al

As used herein, the term hypoxia or hypoxic condition is defined to mean a condition in which oxygen in one or more tissues of a mammal is lowered below physiologic levels, e.g., to a less than optimal level

Treatment : Transfusions: Hb values fall below 7gr / dl Facial deformations Poor growth Bone expansion Increased splenomegaly Treatment of Fe overload Splenectomy Chelation therapy: Administer Iron chelators for elimination in urine and feces (from 10 to 20 transfusions or at ferritin levels above 1000 ng/ml)

The fate of the liposomes in the cell cultures was assessed by fluorescence microscopy using a NIKON TE2000-E inverted microscope, triple band filter for Rhodamine, GFP and DAPI at 2Ox or 6Ox magnification

10.1016/s0891-5849(01)00460-9 583