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10.1016/S0021-9258(19)86782-0 47

10.1016/j.toxlet.2020.01.023 Summary Keywords hydrogen, tetrandrine, oxidative stress, EndMT, pulmonary fibrosis Citation Xiao K, Li M, Mu Y, Sun Y, Wang S, Chen S, Ma J, Cao M, Yang Y, Shao H, Ding X, Cui G and Du Z (2026) Hydrogen improves the efficacy of tetrandrine in the treatment of silicosis by inhibiting vascular endothelial mesenchymal transition caused by oxidative stress

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This in turn, first activates the PI3K/Akt/mTOR, PI3K/Akt/FoxO, or Ras/MAPK/(ERK-1/2) pathways that have important roles in cancer cell growth and carcinogenesis

Both of these options pose a risk to the patient: increasing the rate can result in fluid overload and increasing the concentration risks hyperosmolarity