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It could also be due to the possibility that multiple CpG sites must be altered, or that other interactors, such as histone modifications and non-coding RNAs, are required in addition to DNA methylation in order to alter gene expression

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Archived from the original on March 29, 2026

52 Thus, these controversial findings of NAMPT-catalyzed NAD + biosynthesis overage might come from the differential cell type and tissue context, which will be elucidated in future studies