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With respect to treatment options, the use of Cu chelators, Clioquinol, or tetrathiomolybdate, mitigates the pathology and behavioral abnormalities of the R6/2 HD mouse model

Small 2205687

Siegrist, M.S

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To confirm that the pathway activity inferred from gene expression data reflected a dependency of NB on the antioxidant pathways, we assessed the effect of RNA interference (RNAi) knockdown or CRISPR-mediated knockout of the three rate-limiting enzymes