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Disclosures: Binu John: Exact Sciences: Grant/Research Support, Genentech: Grant/Research Support, Glycotest, Inc: Grant/Research Support, Gilead: Grant/Research Support, Exelixis: Consultant, Takeda: Grant/Research Support, GlaxoSmithKline: Consultant, Astra Zeneca: Consultant, Yangyang Deng: Nothing to Disclose, Amit Singal: Genentech: Consultant, AstraZeneca: Consultant, Bayer: Consultant, Eisai: Consultant, Exelixis: Consultant, Merck: Consultant, Elevar: Consultant, FujiFilm Medical Sciences: Consultant, Exact Sciences: Consultant, Glycotest: Consultant, Boston Scientific: Consultant, Sirtex: Consultant, HistoSonics: Consultant, Bassam Dahman: Nothing to Disclose 1015 GUT MICROBE-PRODUCED INDOLE-3-PROPIONIC ACID ALLEVIATES HEPATITIS B-RELATED FIBROSIS BY REGULATING TH17 CELL DIFFERENTIATION THROUGH GLUCOSE METABOLISM REPROGRAMMING Fangyuan Chen 1 Siqi Wang 1 Linlin Zheng 1 Shuyu Li 1 Jian Wu 2 Wei Jiang 3 , 1 Fudan University, Zhongshan Hospital, 2 Fudan University, 3 Fudan Univertisy, Zhongshan Hospital Background: T helper (Th) 17 play a crucial role in promoting HSC activation in fibrotic progression by producing interleukin-17 (IL-17)

doi: 10.1016/j.bcp.2021.114769 60 CeremugaMStelaMJanikEGorniakLSynowiecESliwinskiTet al

Evidence for the Exact BPC-157 + TB-500 Combination Combining two separately discussed molecules does not create combination evidence

The peptide activates survival pathways including Akt signaling, promotes stem cell recruitment and differentiation, and upregulates matrix metalloproteinases (MMPs) for tissue remodeling