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Experimental data on animal models have suggested that GIP suppresses peripheral arterial remodeling, thus showing an anti-atherosclerotic activity, by acting on receptors in the heart and vessels." Outcomes of clinical trials The first clinical trial to test the clinical efficacy of TZP was the SURPASS program, a six-stage trial conducted on three separate cohorts Japanese (SURPASS-J), Asian-Pacific (SURPASS-AP), and the cardiovascular outcome trial (SURPASS-CVOT)

While the specific amount needed varies by individual and climate, most adults benefit from drinking approximately two liters of fluids daily, adjusting for activity level and environmental conditions

The reaction was stopped by increasing the temperature to 100 C for 5 min

10.1667/RR14306.1 109 GourbeyreP.DeneryS.BodinierM

The physiological mechanism is plausible, the published research supports the indication, and the side-effect profile is favorable