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Uncertainty regarding appropriate preclinical models, particularly for chronic versus acute infections, further increases development risk and cost (Theocharopoulos et al., 2020), discouraging investment and slowing translation of ID-ADCs ( 10.7 The translational valley of death The convergence of scientific, manufacturing, and regulatory challenges culminates in a pronounced translational valley of death, especially for neglected tropical diseases

Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI

For example, a patient with a history consistent with IgE-mediated reaction to the antimicrobial sulfonamide trimethoprim-sulfamethoxazole can receive celecoxib, chlorthiazide, furosemide, or other nonantimicrobial sulfonamides, as indicated

doi:10.1111/j.1445-5994.1989.tb00349.x

Independently Tested Each batch is independently tested to ensure product purity and dosage