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Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice

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Interestingly, although increased GLUD1 expression decreased mammary epithelial cell proliferation, the reverse occurred in colorectal carcinoma cells, where increased GLUD expression caused increased proliferation, migration and invasion (Liu et al, 2015)

Nrf2-dependent transcription is repressed by Keap1 under basal conditions, when cells are exposed to oxidative stress, Nrf2 escapes repression and activates antioxidant responsive element (ARE)-dependent gene expression ( 3.1.7 COPZ1/NCOA4/FTH1 COPZ1 expression is upregulated in GBM cell lines and it has a tendency to negatively regulate the activity of NCOA4