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2A, 2 B and 2 C show (A) Urinary (B) Fecal elimination and (C) tissue retention respectively (expressed as percent of administered dose) of IV administered Co-60 in Fisher F344 rats: effect of repetitive treatment (once daily for 5 days) with ReadiSorb (oral) or non-formulated reduced glutathione (oral or IV)

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doi: 10.1007/s13197-013-0978-y 123

9 METABOLISM AND EXCRETION SPL UNCLASSIFIED SECTION In a pharmacokinetic study where five normal adult male volunteers received an oral dose of [ 3 H-methyl]-L-carnitine following 15 days of a high carnitine diet and additional carnitine supplement, 58 to 65% of the administered radioactive dose was recovered in the urine and feces in 5 to 11 days