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Connexin mutants compromise the lens circulation and cause cataracts through biomineralization

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One of the plausible theories for the pathophysiology of autism is the excitation-inhibition (E/I) imbalance theory 6

The FDA and KMFDS approved a phase III, multicenter, randomized, double-blind, sham-procedure-controlled trial, conducted exclusively in South Korea [166] NCT 04745299, KCT0005954, which did not meet primarily efficacy outcomes [167], though long-term follow-up and safety reporting continues through 2026

On a titration curve, the pK a can be observed as the point of inflection near the center of the plateau. The inflection point is where the curvature changes from concave up to concave down