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Cavallaro RA, Nicchia E, Semplici B, et al

Mitochondrial swelling, vesicle formation, and somatic cristae breakage were observed in the CuSO4-induced kidney injury model, nip3-like protein (NIX)/BNIP3 mRNA and protein levels were significantly upregulated, and the number of mitochondrial and lysosomal fluorescent aggregation sites was increased, suggesting that CuSO4 treatment promotes the onset of BNIP3/NIX-mediated mitophagy, and that co-treatment with CuSO4 and an inhibitor of mitophagy significantly exacerbates mitochondrial dysfunction ( In vivo experiments further confirmed that FLIPUS could alleviate ECM loss and chondrocyte apoptosis in a destabilization of the medial meniscus (DMM) mouse model through mitophagy mediated by FUNDC1, thereby exerting a protective effect on cartilage (Ye et al., 2023)

Carbamazepine toxicity after starting combination antiretroviral therapy including ritonavir and efavirenz

10.1038/s41467-020-14993-8 35 GuillaudL.DimitrovD.TakahashiT