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Astrocytes sense extracellular changes through receptors such as pattern recognition receptors and cytokine receptors, detecting pathogens, A aggregates or inflammatory mediators 4,41

The microbiome is altered in response to genetic influences (Nagpal et al., 2017), and lifestyle (Lee S

Oxidative stress and neuroinflammation significantly contribute to the pathophysiology of psychiatric disorders

Remarkably, in terms of long-term impacts, the mice that received MSCs continuously maintained a 60%80% conception rate over a second breeding cycle, whereas the group treated with EXOs relapsed into infertility during the same period (Park et al., 2023)

In addition, most of the effective analgesics in NP failed to provide symptomatic relief of CIPN and often exhibit side effects (Han and Smith, In general, unlike other types of NP (including those induced by trauma and diabetes) axonal degeneration in peripheral nerves is not present in CIPN (Ji et al., Regarding to CIPN induced by the taxanes, Duggett et al