The amide on the functional group is not basic
doi: 10.1126/science.285.5424.110
35 TamuraA.MatsunobuT.TamuraR.KawauchiS.SatoS.ShiotaniA
This label positioning preserves the isotope tag during metabolic processing, as FA elongation, further desaturation, and the major truncation reaction (-oxidation) exclusively occur at the carboxy-terminus in mammalian cells 39
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