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Clinical findings In 1971, Folkman [1] proposed that new blood vessel formation (angiogenesis) is necessary for the progression of solid tumours beyond a size of a few millimetres cube and that blocking angiogenesis in tumours might be an effective means of maintaining or inducing dormancy and preventing metastasis

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The previous interactions contribute to the activation of the peripheral immune system and primes CNS microglia, creating a neuroinflammatory environment that aggravate behavioral deficits (Manda et al., 2012

This treatment strategy will be cost-effective, easily available worldwide, lower toxicity on health cells, and could eliminate the burden of epilepsy