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The most affected brain regions containing a high amount of neuromelanin and a high concentration of copper are the locus coeruleus and substantia nigra (Davies et al., 2013[106])

doi: 10.1016/j.freeradbiomed.2023.03.027 18 ZhaoTYangQXiYXieZShenJLiZet al

After 2 days, the cells were first treated with the indicated compounds for 4 h and then with 30 or 100 nM MZ1 for an additional 2 h

Recent results indicate that Dato-DXd combined with durvalumab demonstrates impressive efficacy and manageable safety and tolerability

The involvement of ERK1/2 and p38 MAPK in the premature senescence of melanocytes induced by H 2 O 2 through a p53-independent p21 pathway