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Short NJ, Kantarjian HM, O'Brien SM, Ravandi F, Thomas DA, Garcia-Manero G, Daver NG, Borthakur G , Jain N, Konopleva M, Sasaki K, Pemmaraju N, Alvarado Y, Jacob J, Garris R, Thompson PA, Cortes JE, Jabbour EJ

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Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes

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lactis HN019 was also shown to reduce transit time and relieve symptoms compared with placebo in a trial with 100 participants whose average stool frequency at baseline was 13 per week