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Vitamin B deficiency from the perspective of a practicing hematologist

In hepatocytes and adipocytes it reduces the activity of key lipogenic enzymes: Acetyl-CoA carboxylase (ACC) , a key step in fatty acid synthesis Fatty acid synthase (FAS) , the enzyme creating long chains of fatty acids Lipoprotein lipase (LPL) in adipocytes, reduces uptake of circulating triglycerides into fat cells Imagine it as turning valves in a pipeline, you close the inflow (lipogenesis), open the outflow (lipolysis)

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Therefore, measuring the levels of MMA in the blood can help diagnose a vitamin B-12 deficiency, especially in an early, asymptomatic state