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Lack of glutathione can overload the liver, hampering its ability to detoxify the body

Wachter A, Wolf S, Steininger H et al (2004) Differential targeting of GSH1 and GSH2 is achieved by multiple transcription initiation: implications for the compartmentation of glutathione biosynthesis in the Brassicaceae: differential targeting of GSH1 and GSH2

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There are also cancer connections: a 2013 meta-analysis found acetaminophen associated with a significantly increased risk of kidney cancer, and a 2011 study of more than 64,000 older adults found acetaminophen use associated with several blood cancers, including myeloid neoplasms, non-Hodgkin lymphomas, and plasma cell disorders such as multiple myeloma