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When DNA damage exceeds the repair capacity of the cell, it triggers cell cycle arrest or activates signaling pathways such as p53, leading to apoptosis or necrosis (Zhou et al., 2023)

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An additional increase of the increased eNOS mRNA level occurred but so did a decrease of the increased COX-2 mRNA levels, as well as a consistently normal level of NO, and a decrease of the increased MDA values almost to the normal level [43]

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