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Oxidative stress caused by physical/emotional stress, strenuous exercise, exposure to environmental toxins, and immune stress can all cause an increase in free radicals, which may cause oxidative stress and deplete glutathione

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A very recent, 2016 research article compared the topical moisturizing effect of crosslinked HA (not Hylan B gel specifically, but something called Resilient HA or RHA), HMW-HA and LMW-HA and found that "TEWL (that is trans-epidermal water loss, the water that evaporates from the skin) was reduced by 27.8% with RHA, and by 15.6% with HMW HA, but increased by 55.5% with LMW HA." (You can read much more about HMW and LMW HA here in the geeky details section.) All in all, we think Sodium Hyaluronate Crosspolymer is an awesome version of HA , probably superior to traditional versions, so be happy to spot it on the ingredient list

Based on the results of a previous in vitro study, hydroquinone 4% microemulsions showed higher amounts of drug release, higher drug stability, and reduced skin irritation and skin layer disturbance in comparison to the conventional hydroquinone cream (stnda Okur et al., 2019)

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