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PubMed Central , Genome Research , vol

They promote the expression of catabolic enzymes (e.g., MMP-1, -2, -3, -13, and ADAMTS-4/5) and inhibit anabolic proteins like aggrecan and collagen II by activating signaling pathways such as NF-B, MAPK, and Toll-like receptors (TLR), ultimately leading to ECM degradation and tissue destruction (Yang et al., 2025

Additionally, DMD and HD exhibited relatively high proportions of DHT uptake (Fig

In Parkinson's disease, however, glutathione may theoretically help slow the disease by reducing the oxidative stress that damages dopamine neurons

The weight loss curves had not plateaued at week 26, suggesting that longer treatment periods would yield even greater reductions