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FAC-induced lipid peroxidation accumulation in primary epithelial cells was measured by a fluorescent lipid probe, C11-BODIPY, and this increase was suppressed by ferroptosis inhibitors, ferrostatin-1 and liproxstatin-1 (Fig

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Difference #4: Different Primary Benefits For younger adults: Melatonin primarily helps with: Circadian timing (jet lag, shift work) Sleep onset (falling asleep) For older adults: Melatonin helps with: Sleep maintenance (staying asleep) Sleep quality (more restorative sleep) Earlier sleep phase (if desired) Circadian rhythm stability The shift: Older adults benefit more from melatonin's effect on sleep quality and maintenance than just onset