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Finding the right person was difficult because many at the time, like Fraser, were highly sceptical about the clinical potential of RIA

Salceda S, Caro J: Hypoxia-inducible factor-1 (HIF-1) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions: Its stabilization by hypoxia depends on redox-induced changes

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4, short-term priorities focus on improving the clinical interpretability of organelle-specific zinc dyshomeostasis in vivo, whereas long-term efforts aim to move beyond generalized supplementation toward interventions capable of modulating zinc handling with subcellular precision