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Keywords: Cardiovascular diseases , exercise , hydroxymethylglutaryl-CoA reductase inhibitors INTRODUCTION Physical activity reduces the risk of cardiovascular disease (CVD), both directly and by reducing other risk factors such as unhealthy lipid profiles, blood pressure, insulin resistance, and obesity

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Recently, near-infrared spectroscopy (NIRS) was developed as a readily available brain functional imaging technology in daily clinical settings 32,33,34,35,36,37,38