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For example, polymorphisms that alter the expression of the DNA excision repair protein ERCC-1 (excision repair cross-complementing group 1) have been suggested to be involved in cisplatin- and oxaliplatin-induced cytotoxicity, though no clinical study to date has shown an association with CIPN (Inada et al., 2010)

AIs can be divided into two groups based on their chemical structure: steroidal (analogs of androstenedione, exemestane, formestane, and testolactone), which provide irreversible aromatase inhibition, and non-steroidal (anastrozole and letrozole), which provide reversible inhibition (Ahmad, 2015)

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Clinicians assess baseline hormone panels and sleep studies to finetune dose size and frequency, ensuring each patients circadian profile receives optimal peptide support daily