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ADMA causes ROS generation to rise when NO levels fall

Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle

2.5 RNA isolation and quantitative real-time PCR Total RNA was extracted from HCECs using the TRIzol reagent (Vazyme Biotech Co., Ltd., Nanjing, China), according to the manufacturers instructions

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