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People with chronic obstructive pulmonary disease (COPD) experience long-term oxidative damage and inflammation of lung tissue, which causes airways to constrict, leading to shortness of breath and coughing

Blast cells of peripheral blood from patients with acute myeloid leukemia also demonstrated a similar low level of expression [41]

Gluathione l g

Ca 2+ overload can trigger the activation of multiple signaling pathways, such as the calcineurin/nuclear factor of activated T-cells pathway [88] and the cyclic adenosine monophosphate/protein kinase A pathway [89], in addition to exerting significant effects on mitochondrial function

Other prominent immunotoxicants include per- and polyfluoroalkyl substances (PFAS) [36], polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons (PAHs) [37]