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Their functions include pathogen phagocytosis, necrotic debris degradation, and time-ordered release of pro-healing factors (e.g., VEGF, PDGF), thereby regulating the transition from inflammation to repair homeostasis

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The researchers encapsulated both pegylated IGF-1 mimics and control formulations (unpegylated IGF-1 mimics and rhIGF-1) within polycaprolactone-based matrices, enabling localized and sustained delivery to the repaired tendons

Thiostrepton (TST, purity ~99%), RSL3 (purity ~99%), and ferrostatin-1 (Fer-1, purity ~99%) were purchased from MedChemExpress (MCE, USA) and dissolved in dimethyl sulfoxide (DMSO)

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