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In summary, this study suggests that GlyNAC supplementation is safe and well tolerated in older adults and may support GSH biosynthesis in individuals with increased oxidative stress and compromised GSH stores

These active components help reduce abnormal -syn aggregation, block its neurotoxic effects, inhibit the apoptosis of dopaminergic neurons in the substantia nigra, regulate microglial activation, reduce the release of pro-inflammatory factors such as TNF- and IL-1, enhance antioxidant defense systems (e.g., by upregulating the Nrf2/HO-1 pathway) to mitigate oxidative stress damage, and promote neuroregeneration and synaptic repair

Protein prenylation in islet -cell function in health and diabetes: putting the pieces of the puzzle together

C.NosedaG.FragiacomoC.ColomboL.CraveriA.et al (1984)

Grant CM, Maciver FH, Dawes IW (1997) Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide y-glutamylcysteine