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One proposed hypothesis, as yet untested, is that high-dose folic acid supplements cause depletion of the transport protein holotranscobalamin in serum, thus exacerbating B12 deficiency

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Specifically, under 425.640(f)(1)(i) we specify that an eligible ACO entering an agreement period beginning on January 1, 2026, or in subsequent years will receive quarterly prepaid shared savings payments for the entirety of the ACO's agreement period unless the payment is withheld or terminated pursuant to 425.640(h)