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Of the eight isozymes of GPx, at least four, including GPx1, GPx2, GPx3, and GPx4 in mammals, contain selenocysteine (Sec) in their active site

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According to the decrease of SOD3 expression in aging mice and human skin tissues, SOD1-deficient mice showing muscle aging in early adulthood, mice lacking SOD2 in mitochondria partially showing proton leakage, respiratory depression and increased mitochondrial oxidative damage, etc., all confirmed that SODs are indispensable in anti-aging

Ann Pharmacother 57(3):341347