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doi: 6 10.1007/s00210-00016-01247-00211

We have previously described a functional interplay between BCR and NOTCH1 pathways that creates a positive feedback loop amplifying leukemic cell activation [21]

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In addition, pathogenic mutations in the genes ATPase 13A2 ( ATP13A2 ) (Bras et al., 2012), phospholipase A2 ( PLA2G6 ) (Gregory et al., 2008) F-Box protein 7 ( FBXO7 ) (Shojaee et al., 2008), DNA J Heat Shock Protein Family (Hsp40) Member C6 ( DNAJC6 ) (Edvardson et al., 2012) and Vacuolar Protein Sorting 13 Homolog C ( VPS13C ) (Lesage et al., 2016) are linked to autosomal recessive, early-onset atypical parkinsonism that often comprises additional clinical features such as pyramidal degeneration, ataxia or dementia, with or without LBs