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For 14 of 19 patients with an organic acidemia, TMAO levels were greater than 15 times the median level of the reference population (multiples of the median, MoM) with an overall average TMAO level in the organic acidemia cohort of 65 MoM ( p -value = 2.19 10 8 )

Each mouse commenced the experiment in one arm, designated the home arm, and was allowed to explore for 10 min

GSH cannot be supplemented through oral intake because it is highly digestible in the gut, which reduces its effectiveness [48]

The GROUPER software is used both to classify past cases to measure relative hospital resource consumption to establish the MS-LTC-DRG relative weights and to classify current cases for purposes of determining payment

Authors' contributions JC made substantial contributions to conception and design of the study, acquisition, analysis and interpretation of data, revised the manuscript critically for important intellectual content, and was a major contributor to writing the manuscript