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In the LPS-induced acute lung injury mouse model, treatment of GHK-Cu also significantly suppressed TNF- and IL-6 expression with a significant decrease of both NF-B p65 and p38 MAPK signaling, suggesting that GHK-Cu is useful for the development of novel anti-inflammatory therapies [22]

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By improving CNS bioavailability, enabling more precise targeting, and reducing systemic toxicity, these systems offer a promising framework for enhancing the translational success of both existing and emerging AD therapies (Figure 1)

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Here is what they found: Local glucocorticoid injections are often used to treat joint, soft tissue, or spinal pain, but the systemic side effects associated with these injections are poorly understood and not well recognized