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Much of what Randolph wrote is considered pseudoscience by the medical community, and the American Medical Association still doesnt recognize MCS as a disease

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A prospective study involving IBD patients with aberrant metabolic profiles recorded an increase in HPRT activity following the thiopurine-allopurinol therapy but no effect on TPMT activity, suggesting that allopurinol may affect HPRT through an unknown mechanism (Seinen et al., 2013)

Pliyev, B

2019 Jan 1;6(12):3525u201338