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Comp Immunol Microbiol Infect Dis

Lactate accumulation associated with aerobic glycolysis further contributes to an immunosuppressive microenvironment by inducing T-cell exhaustion [173], suppressing interferon-gamma (IFN-) secretion by natural killer cells [174], promoting M2-like polarization of tumor-associated macrophages [175], and impairing dendritic cell-mediated immune responses [176]

Plus, vitamin-C, with its antioxidant properties, reduces the count of the free radicals, which cause oxidative stress and skin damage

10.1007/s12016-021-08899-6 Clin Rev Allergy Immunol

Step 3: The treatment area is sanitised, and an intravenous cannula is gently inserted into a suitable vein