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Along these lines it is interesting that elevated expression of mammalian 14-3-3 can promote alpha synuclein extrusion 63 , akin to our finding that 14-3-3 protein FTT-2 is required for efficient exophergenesis and can drive enhanced exopher production when over-expressed in C

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They can induce cardiac remodeling and electrophysiological changes, which can lead to deadly arrhythmias (87, 88)

In all experiments, age-matched mice were used (unless otherwise stated), WT littermates served as controls, and treatment was randomly assigned to control for cage effect

3a)a phenomenon that was previously observed in cell lines and tumour models 39,40,41