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RSFCsymptom association analyses To explore the relationship between SCAN-subcortical RSFC and both motor and non-motor symptoms, we performed separate partial least squares (PLS) regression analyses linking RSFC between six subcortical ROIs and the cortical SCAN to each of four clinical measuresMDS-UPDRS-III, MMSE, HAMA and HAMDin the PIPD dataset

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The separated peptides were subsequently analyzed using a Q ExactiveTM Plus hybrid quadrupole-Orbitrap mass spectrometer (Thermo, USA)

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