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G., Ko, J

Tryptophan and its degradation product kynurenine are known markers of systemic immune activation

10.1007/s13596-021-00610-6 179

It is this dynamic that has made measurement of serum ceruloplasmin the primary screening test for Wilsons.16 Ultimately, the excess retained copper in the hepatocytes of Wilsons patients leads to toxic injury to the cell and eventually spillage of copper into the circulation, where it may be deposited in other organs such as the brain, cornea, and kidneys