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Additionally, ROS activates stress-sensitive kinases (JNK, p38 MAPK) that phosphorylate IRS-2, accelerating its proteasomal degradation and further impairing -cell survival (Liu et al., 2020)

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however, absorption is markedly increased when the skin has lost its keratin layer and can be increased by inflammation and/or diseases of the epidermal barrier (e.g., psoriasis, eczema)

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TXNDC12 (thioredoxin domain-containing protein 12), also known as ERp18 or ERp19, plays a role in inhibiting ferroptosis independently of GPX4 in human leukemia cells within the ER [134]

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Cancer Science, 98 , 329333

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In addition, to increase corneal passing of N-acetylcarnosine, this prodrug has been also loaded in gold nanoparticles with good results in terms of biosafety and bioavailability [80]

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