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doi: 10.1053/j.gastro.2016.10.046 98 de LartigueG

Nonclinical, in vitro proof of concept has been achieved for NPI-001 in HCCAA, with the demonstration that NPI-001 catabolizes L68Q-hCC-induced high molecular weight complexes that cause HCCA

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10.1016/j.pep.2006.05.019 Saleh L, Southworth MW, Considine N, O'Neill C, Benner J, Bollinger JM Jr, Perler FB: Branched intermediate formation is the slowest step in the protein splicing reaction of the Ala1 KlbA intein from Methanococcus jannaschii