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[DOI] [PubMed] [Google Scholar] 296.Makrecka M, Kuka J, Volska K, Antone U, Sevostjanovs E, Cirule H, et al

At the initial baseline visit, serial venous sampling performed after oral d 3 -l-carnitine challenge revealed rapid increases in plasma concentrations of d 3 -l-carnitine, and subsequent increases in d 3 -BB and d 3 -TMAO following a lag phase (Figure 1, AC, filled circles)

This pathway is involved in enhancing therapeutic efficacy (e.g., 20(S)-Rg3 combined with sorafenib for hepatocellular carcinoma), reducing toxicity (Astragaloside IV counteracts doxorubicin-induced nephrotoxicity), and reversing drug resistance (Saikosaponin A combined with gemcitabine for intrahepatic cholangiocarcinoma)

2016 Feb;55(1):207-17