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Sharma A, Bansal S, Nagpal RK

Zhang M, Sun D, Huang H, Yang D, Song X, Feng W, Jing X, Chen Y

Metformin has been shown to reduce the accumulation of AGEs in the sciatic nerves of rats with streptozotocin (STZ)-induced diabetes by activating AMPK, leading to improved nerve conduction velocity, and the attenuation of heat and mechanical hyperalgesia (59)

PACS2/CPT1A/DHODH signaling may function by modulating mitochondrial activity in cardiomyocytes ( 2.2.2.4 GTP cyclohydrolase 1/tetrahydrobiopterin The GCH1/BH4 pathway involves a fundamental enzyme participating in various critical cellular metabolic processes, with GCH1 being the rate-limiting enzyme for BH4 synthesis ( Figure 2B )

Possible associations between behavioural reaction time slowing and total negative symptoms ( r = 0.351, CI 95% [ 0.578, 0.0747], p = 0.0143) and between total positive symptoms and Glx ( r = 0.335, CI 95% [ 0.57, 0.0496], p = 0.0228) did not survive strict correction for multiple comparisons (p holm = 0.3, 0.46 respectively) in the present context