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Both cortisol and cortisone levels follow a daily rhythm, peaking in the morning (daytime) and corresponding with the maternal hypothalamic-pituitary-adrenal axis activity [49]

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Neratinib, an irreversible pan-TKI, targets EGFR/HER1, HER2, and HER4 of the ERBB tyrosine kinase family (Rabindran et al., 2004)

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Correlating with prevention of cognitive defects, lithium carbonate improved spatial reference and working memory in a rat intra-hippocampal injection model of AD and reversed reductions in anti-inflammatory (IL-4) and increases in pro-inflammatory (IL-1, TNF) cytokines in the frontal cortex and hippocampus (Budni et al., The molecular mediators of lithiums anti-inflammatory effects in dementia models are unclear, but correlative evidence suggest that GSK-3, toll-like receptor 4 (TLR4), signal transducer and activator of transcription (STAT) and nuclear factor-B (NFB) pathways may play a causal role (Jope et al., 2017