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Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses

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Pairing vitamin D3 with vitamin K2 helps improve calcium absorption and inflammation control

Second, the peptide may reduce muscle contractions that contribute to dynamic wrinkle formation, similar to but much weaker than botulinum toxin effects

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