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As with all GLP-1 agonists, long-term post-marketing surveillance will be essential to characterize the pancreatic safety profile with greater statistical precision, particularly for rare events such as acute pancreatitis (estimated background rate of approximately 35 per 100,000 person-years in the general population) and the theoretical concern about pancreatic cancer

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273 Moreover, GLP-1RAs could decelerate the progression of OA and mitigate pathological damage in a rat OA model

And unlike some side effects that require ongoing management throughout the entire course of treatment, heartburn tends to follow a clear arc of onset, peak, and resolution that gives you a light at the end of the tunnel

Accordingly, our results showed that CSF-derived Acly and Acat2, an enzyme downstream of Acly, are both downregulated following targeting CD38 in 5xFAD mice