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Among genetic predispositions, specific human leukocyte antigen (HLA) genes are strongly implicated, such as HLA-B51 in BD ( Figure 1 ) ( Figure 1 Based on current evidence, we hypothesize that dysbiosis of the gut microbiome and its metabolites trigger gut inflammation and increase intestinal permeability (leaky gut)

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The reference electrode was placed 34 mm subdermally above the ankle near the tendons