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When cells respond to oxidative stress, large amounts of highly reactive and toxic ROS are produced and lead to adverse changes in cellular components such as proteins, lipids, and DNA damage [41].Cell membrane is particularly vulnerable to ROS damage due to its high polyunsaturated fatty acids (PUFA), called lipid peroxidation, which is the most significant feature of ferroptosis

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The emergence and spread of carbapenemase- producing Enterobacteriaceae (CPE) has become a major problem for clinical and public health since they are resistant to all -lactam antibiotics and also frequently to other antibiotic classes, limiting the treatment options

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