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Nonmotor symptoms are less severe but include sleep, cognitive, and psychiatric disturbances [1, 6, 8,9,10,11,12,13]

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Am J Pathol 184(10):27302741 Zhou HZ, Ma X, Gray MO, Zhu BQ, Nguyen AP, Baker AJ et al (2007) Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction