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The underlying genetic flaw responsible for disease inheritance in these two families was found to be mutations in the CARD14 gene, according to next-generation sequencing

1217 The percentage of people with generalized joint hypermobility who are eventually diagnosed with hypermobile EDS/hypermobility spectrum disorders is unknown

This research was supported by MEXT/JSPS KAKENHI (23H02887 to S

Lipid peroxidation, DNA damage, and protein oxidation within spermatozoa result from OS, which occurs due to an imbalance between endogenous antioxidant defenses and reactive oxygen species (ROS) generation [2, 3]